Pharmacogenetics and Pharmacogenomics
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چکیده
The individual differences in response to administered substance (medicament) were observed throughout the whole history of humankind. Pythagoras is thought to be one of the first to observe pharmaco/nutrigenetic interaction as he found out that only some people will get sick after eating fava beans, but others will not. It took approximately 2400 years to elucidate the basis of this observation, the defect of glucose-6-phosphate dehydrogenase enzyme, that causes hemolytic anemia (2) but only after exposure to fresh flava beans or antimalaric drug primachine (but also to acetylsalicylic acid, phenacetine or sulphonamides).
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